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In animals, probiotics play a crucial role in eliminating potential pathogens by producing inhibitory substances or competing directly for space, resources, and oxygen in the gut (Raheem et al., 2021

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But investigators found increased acetoacetate in the aged rat hippocampus (Choi et al., 2024) suggesting there may be an oxidizing redox shift in the acetoacetate/beta-hydroxybutyrate, reflecting the mitochondrial [NAD + ]/[NADH] in the hippocampus with aging, consistent with the loss of NADH in mouse neuronal mitochondria with aging (Dong et al., 2019a)