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Reasons for fatigue Fatigue stems from physical or mental factors, including things like: Metabolic conditions such as diabetes, kidney disease, Cushing syndrome, and thyroid conditions Mental health issues such as depression, stress, eating disorders, anxiety, and burnout Cardiovascular conditions affecting blood flow, such as arrhythmias, heart disease, and heart failure Medications such as antidepressants, antihistamines, steroids, statins, and sedatives Sleep problems due to insomnia, narcolepsy, jet lag, and sleep apnea Chemical imbalances due to too little or too much of various essential nutrients, vitamins, and minerals Facts about B12 deficiency Also referred to as cobalamin deficiency and named after the scientific term for this water-soluble nutrient, a B12 deficiency can result from low dietary intake or from your body not absorbing the vitamin properly
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According to the NIH Office of Dietary Supplements, functional B12 deficiency is most commonly seen in patients with one or more of the following: Age over 50 — stomach acid production declines with age, and stomach acid is required to free B12 from food PPI or H2 blocker use — reflux medications suppress the acid needed for B12 absorption Metformin use, which interferes with B12 absorption directly Vegan or vegetarian diets — B12 is found almost exclusively in animal products Gut conditions including celiac, IBS, SIBO, and Crohn’s MTHFR mutations that affect how B12 is metabolized once absorbed Heavy alcohol use The symptoms of low B12 are easy to dismiss: fatigue, brain fog, low mood, tingling in the hands or feet, weakness, and shortness of breath on mild exertion
