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Kovalzon, Kalikhevich and Churkina had already reported in 1986 that (D-Trp1)DSIP, made more resistant to aminopeptidases, increased slow-wave sleep by 40% in rabbits at 0.7, 7 and 70 micrograms per kilogram intracerebroventricularly and by 25% intravenously within a narrow 30 to 70 micrograms per kilogram range, while unmodified DSIP had not been found hypnogenic in the same hands

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Mechanism of M2 macrophage-derived extracellular vesicles carrying lncRNA MEG3 in inflammatory responses in ulcerative colitis