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Interestingly, oncogenic proteins have been found in tumor-cell derived EVs which could remodel recipient tumor and stromal cells in the TME to favor tumor progression [146]

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Firefly luciferase-labeled H1975 (H1975/Luc) or HCC827 cells (1 × 10 6 ) were surgically implanted into the lung parenchyma of female, athymic nude mice as previously described [49]