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The levels of homocysteine have been correlated with the severity of AD in several studies (Kitzlerová et al., 2014

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14 , 15 Approximately 80% of patients with PCT are affected by the acquired, sporadic type PCT, whereas the presence of a germline heterozygous mutation of uroporphyrinogen III decarboxylase (UROD) causes the inherited form of the disease (familial PCT, F-PCT)