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As vitamin B12 is water-soluble, excessive intake is unlikely, as anything you don’t need your body will excrete in urine

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Elevated levels of sphingosine 1-phosphate receptor 1, which contributes to blood-brain barrier permeability in epileptic brains through the promotion of neuroinflammation, were detected alongside reduced levels of tight junction proteins in mice induced with pilocarpine-induced status epilepticus (168)