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Vitamin B 1 deficiency causes overexpression of pro-inflammatory cytokines such as interleukin (IL)-1, IL-6, and tumor necrosis factor-alpha (TNF-α) as well as increased expression of CD40 and CD40 ligand by microglial cells and astrocytes, which eventually leads to the death of neuron cells [18,19]
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(ii) For each measure that is submitted, if applicable, and impacted by significant changes or errors prior to the applicable data submission deadline at § 512.720(d), performance is based on data for 9 consecutive months of the applicable ASM performance year
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