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Circulating platelet-neutrophil complexes represent a subpopulation of activated neutrophils primed for adhesion, phagocytosis and intracellular killing

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These requirements are the protection of the epithelium (“epithelial pathway”) and endothelium (“endothelial pathway”), and the maintenance of gastrointestinal mucosal integrity to obtain a large beneficial effect inside and outside the gastrointestinal tract