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The animals were treated daily during five weeks with L-NAME (10 mg/kg b.w.), L-arginine (100 mg/kg b.w.), NaBPC157 (10 µg/kg b.w.) and their combinations (L-NAME + NaBPC157, L-NAME + L-arginine) intraperitoneally

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Furthermore, the apoptosis-inducing effect and mechanism of FOXO4-DRI in a serum limitation-induced senescent fibroblast and organ culture models of keloids were examined