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FIGURE 6 13.1 Major phytochemical classes and cardiovascular relevance 13.1.1 Polyphenols Flavonoids emerged as promising multi-target cardioprotective agents

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These results may explain the ineffectiveness of the 10 μM dose of LA treatment, as the increased formation of peptide fragments (particularly LA fragment 2) may share enough similarities to the Zot and zonulin receptor-binding motif (G XXX VQ X G) to competitively inhibit LA binding to EGFR and/or PAR2