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EDTA yielded essentially uninterpretable increases in urinary elimination over 48 hours in one study that was significantly methodologically compromised [104]

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3.3 Targeting VEGF-mediated tumor angiogenesis Vascular endothelial growth factor (VEGF) drives tumor angiogenesis through hypoxia-inducible factor 1α (HIF-1α)-mediated transcriptional regulation, a process amplified by oncogene signals, growth factors, and hypoxic stress