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Current research has significantly explored the bidirectional relationship between dysregulated brain metabolism and sleep impairments in influencing aging as well as age-associated neurocognitive deficits, and suggests that alterations in any one of them exacerbate the other, leading to accelerated aging and neurodegeneration ( vice versa , since impaired glucose utilization, lipid metabolism as well as oxidative stress in the mitochondria, are altered as we age and conversely, exacerbated ROS and a decline in bioenergetics in neuroglial cells, aggravates aging and cognition (Bratic and Larsson, 2013
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