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The crosstalk between oxidative stress and immunometabolism represents a shared mechanistic nexus in both aging and tumorigenesis The role of antioxidant systems in oxidative stress A.TRX1 maintains nucleotide biosynthesis The rate-limiting step in nucleotide biosynthesis during the final phase of the PPP is catalyzed by ribonucleotide reductase (RNR), which reduces ribonucleotides to the corresponding 2’-deoxyribonucleotides (dNTPs), which are essential components of DNA 147,148,149

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doi: 10.1080/09273948.2023.2260464