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‘For instance, IGF-1 is made in the liver, hence an undiagnosed precancerous liver disease could have prevented the liver from producing normal levels of IGF-1.’ The study demonstrates the power of using population-level approaches to assess the extent to which risk factors apply across the entire cancer spectrum
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In this context, tumor cells counteract the stress response mechanisms, including heat shock response (HSR) and unfolded protein response (UPR) as adaptative mechanisms to survive [4, 5]
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