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For example, administration of 2.4 mg/week of semaglutide (instead of 1 mg used in diabetics) for 68 weeks leads to average losses of 15% of initial body weight, approximately double that in type 2 diabetics (Figure 5A)

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To achieve genetic suppression of the PrP protein in an Atp7b −/− background, we crossed Atp7b −/− and Prnp −/− mice to generate a new Atp7b −/− :Prnp −/− strain