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Pickart's pioneering work, along with subsequent studies published in journals including the Journal of Biological Chemistry and Dermatologic Surgery , has established GHK-Cu as a peptide with broad regenerative potential: Collagen Remodeling: GHK-Cu has been shown to stimulate synthesis of collagen types I, III, and V, along with elastin and decorin, the key components of the extracellular matrix essential for skin structure and wound repair

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Better measurements of specific ROS and RNS species and their covalent modifications of lipids and macromolecules is another important frontier