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When loaded with naringenin and sulfobutylether-β-cyclodextrin, these nanofibers significantly improve the aqueous solubility of naringenin, thereby enhancing its potential for oral absorption (324)

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The term tachyphylaxis refers to the decreased responsiveness of a cell to repeated stimulation with drug, and can be due to both processes of GPCR-transducer uncoupling (acute or short-term desensitization) and GPCR downregulation (long-term desensitization) (Figure 1)

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