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Mutations of the residues relating to FAD-binding, ubiquinone-binding or FAD hydroxylation pockets reduced the NADH oxidation activity of FSP1 proteins (Supplementary Table 2), among which K117A, K292A/M293A/Y295A, R53A mutations of cFSP1 were almost completely inactive in vitro

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Perioral dermatitis frequently does, and patients also report a burning sensation in the affected area