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Right: Degradation of FAT10-Eos-tail (2 μM) by sc 26S proteasomes (100 nM) in the absence or presence of NUB1 (5 μM), indicating that a flexible tail on the substrate can bypass the NUB1 requirement for sc 26S proteasomes

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Gut microbiota changes require vagus nerve integrity to promote depressive-like behaviors in mice