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Although the initial skepticism towards nanoparticle-based therapies, the approval of several drugs-loaded nanoparticles by the FDA underscores the viability and potential of this approach (Table 4)

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Several aggregate prone proteins, like ataxin-1 (SCA1) and ataxin-3, polyglutamine (polyQ)-repeated huntingtin, aggregate-prone α-synuclein A53T and A30P mutants, tau and SOD1 (copper/zinc superoxide dismutase) are predominately degraded by the autophagy pathway [150][151][152][153][154]