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Enzyme specificity was set as C-terminal to Arg and L-Lys as expected using trypsin and LysC as proteases and a maximum of two missed cleavages

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lactis HN019 led to a significant reduction in levels of homocysteine, hydroperoxides and the pro-inflammatory cytokine IL-6, an increase in levels of adiponectin (a protein with anti-inflammatory and insulin-sensitizing activity) and nitric oxide (NOx) metabolites, suggesting an improvement in endothelial function