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Moreover, thiol oxidation of band 3 is associated with the formation of high-molecular-weight aggregates [116], which not only impairs anion exchange capability but also renders band 3 a neoantigen promoting opsonization and splenic macrophage erythrophagocytosis [117]

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Interestingly, as a component of CSE and an agonist of OR51B5, farnesol can also enhance the secretion of IL-8 and IL-6 in A549 cells and inhibit cell activity (39)