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The ECM and metastasis As discussed, changes in the tumor microenvironment through remodeling of the ECM are important for metastatic dissemination
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Vitamin A serves essential functions: it supports vision as a key component of rhodopsin, regulates keratinocyte and myeloid cell differentiation, modulates gene expression by binding to nuclear receptors [retinoic acid receptor (RAR) and retinoid X receptor (RXR)], and plays roles in bone development and immune function ( Acute deficiency is rare in Western countries
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