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When enzymatically cleaved, Telisotuzumab vedotin releases MMAE into the cytosol, causing cell cycle arrest at the G2/M phase and ultimately contributing to tumor cell apoptosis [104]
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The review concluded that NNMT plays important roles in obesity and type 2 diabetes and validated 5-Amino-1MQ as a potent small-molecule NNMT inhibitor that reverses diet-induced metabolic changes, establishing it as a primary research tool for the NNMT pathway
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