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Since secretin, a gastrointestinal hormone produced by the S-cells of the duodenal and jejunal mucosa, was first identified as a substance released upon contact of hydrochloric acid (HCl) with the duodenal mucosa and, to a lesser extent, the jejunal mucosa [2], numerous other gut-derived hormones have been discovered, each playing a crucial role in GI homeostasis and metabolism [3]