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Both quercetin pretreatment groups demonstrated significant dose-dependent protective effects against glyphosate-induced nephrotoxicity, with the high-dose group (Que-50 + Glyp) showing superior protection, reducing damage scores to approximately 0.4–0.5 compared to 1.2–1.5 in the low-dose group (Que-25 + Glyp) as seen in Table 3
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However, the negative regulation of these antioxidant genes results in prolonged inflammation, and a delay in the healing process [34,35,36], and the excess ROS generated during inflammation can lead to cell damage, such as membrane rupture, DNA damage, and protein oxidation
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