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The thiol/disulfide set point for specific Cys residues in proteins is analogous to the NADH-binding sites mentioned above, with the thiol reactivity of individual protein Cys being tuned by location within the protein structure

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Interestingly, higher plasma levels of cystine indicated a high probability of response in patients with non-small cell lung cancer before and after treatment with the immune checkpoint inhibitor nivolumab, which targets programmed cell death protein 1