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The loss of Trim28 is embryonic lethal due in part to defects in the expression of imprinted genes (Messerschmidt et al., 2012) while the loss of Setdb1 leads to a de-repression of retrotransposons and an increase in DNA double strand breaks (Kim et al., 2016)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 91.Liu Z.-Q., Song X.-M., Chen Q.-T., Liu T., Teng J.-T., Zhou K., Luo D.-Q