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This approach has been successfully translated into the clinic as the administration of low-dose IL-2 in patients with cGvHD resulted in great responses owed in part to the promotion of thymic differentiation and peripheral expansion, survival and function of nTregs [49, 50]

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Although there are no reports yet about CO inhibitory effects on atherosclerotic lesions due to hyperlipidemia, there are several lines of evidence and potential mechanisms that make it very likely