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Dysfunction of sleep-wake neuron interactions A key mechanism in normal sleep-wake regulation is the reciprocal inhibition between the VLPO and monoaminergic cell populations, including neurons in the LC, TMN, and DR (Fig

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Safety and efficacy of tirzepatide as an add-on to single oral antihyperglycaemic medication in patients with type 2 diabetes in Japan (SURPASS J-combo): a multicentre, randomised, open-label, parallel-group, phase 3 trial