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In gastric and ovarian cancers, ISA can inhibit PI3K/Akt signaling, leading to lowered ratio of Bcl-2 to Bax that facilitates apoptosis ( In cancers that are closely associated with inflammation, such as glioblastoma, breast cancer and osteosarcoma, NF-κB activation was also inhibited by ISA, and so were the upstream IκB kinase (IKK) and IκB, and downstream COX2 (Wang et al., 2016