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However, the researchers concluded based on their review that “a beneficial effect of a gluten free diet may be expected, since in general, in children as well as in adults, intestinal inflammation and the associated dysbiosis, with or without underlying celiac disease, are known to promote extra intestinal autoimmune diseases.” Therefore, any measure, including a gluten-free diet, that would help to manage gut inflammation in celiac disease patients may positively impact the evolution and perhaps the manifestation of thyroid autoimmunity

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These include direct inhibition of inflammasome components, caspase-1 blockade, modulation of immune responses using anti-inflammatory agents, and targeted manipulation of gut microbiota and bile acid metabolism, which are increasingly recognized for their roles in liver homeostasis and injury response

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