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Figure 1 - from Using the ventrologluteal site for

The Role of the Locus Coeruleus in Withdrawal Symptoms One of the most important brain regions involved in opiate withdrawal is the locus coeruleus

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Make sure the complex you’re taking also contains the active forms of other B vitamins, including B2 (riboflavin-5-phosphate), B6 (pyridoxine-5-phosphate), and B12 (methylcobalamin, adenosylcobalamin, or hydroxycobalamin)