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Despite elevated intracellular GSH levels and increased redox cycling activity, the transcriptomic data indicated downregulation of Gss (glutathione synthetase), Gclc (glutamate cysteine ligase catalytic), and Chac1 (a canonical GSH-degrading enzyme), alongside significant upregulation of Chac2, a less characterized homolog involved in glutathione regulation (Fig
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Build Variation Type:All Capsules
Conditional knockout of Dnmt1 and Dnmt3a in forebrain excitatory neurons results in long-term plasticity abnormalities in the CA1 region, accompanied by learning and memory impairments (Feng et al., 2010)
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