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We have shown that a mutant of human citrin (D66A/T68A/D70A/E77A), where the critical residues of the calcium binding site in EF‐hand 2 are mutated to alanine, rendering the protein unable to bind calcium, has transport activity comparable to wild‐type citrin ([69]
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A randomised double-blind placebo-controlled 12- week feasibility trial of methotrexate added to treatment as usual in early schizophrenia: study protocol for a randomised controlled trial