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Regulatory Actions Targeting 7-Hydroxymitragynine In 2025, the FDA took steps specifically targeting concentrated 7-OH products, including warning letters and a recommendation that the DEA classify concentrated 7-OH products under the Controlled Substances Act

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In addition, the betanin could inhibit low-density lipoprotein (LDL) and lipid membranes peroxidation because of its bioactive composition, modulating ROS production and gene expression to reduce the inflammatory release of cytokines and increase antioxidant enzyme activities (183)