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Other avenues of intervention include amino acid synthesis pathways such as targeting the rate-limiting enzyme phosphoglycerate dehydrogenase (PHGDH) of the serine synthesis pathway 37,38 or indoleamine 2,3-dioxygenase 1 (IDO1), which generates kynurenine from tryptophan 39,40
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138 On the basis of the known biology of TSLP and its overexpression in the esophagus of patients with EoE, it is the likely gene responsible for the genetic association
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