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In regards to oxidative phosphorylation, electron transport chain (ETC) complex inhibitors, which target components of the mitochondrial ETC, such as complex I (e.g., metformin), complex II (e.g., sorafenib), and complex III (e.g., antimycin A), have been investigated for their potential to disrupt oxidative phosphorylation and induce cytotoxicity in cancer cells, including GBMs (Table 1) [149,178,179,180,181]