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Validation studies confirmed the direct targeting of IGF1R, FGFR3, and mTOR, with antisense miR-99a-5p sequences reversing BITC effects (127) (Figure 5)

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In preclinical models BPC-157 is examined for angiogenesis and tendon/gut repair, while TB-500 is studied for cell migration and tissue organisation, which is why the pair is a common subject of combined recovery research