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Metabolic disorders, such as obesity, T2DM, and insulin resistance, have emerged as significant risk factors for the development and progression of HCC [151]
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The other injuries were initiated at periphery (i.e., nerve transection [79], abdominal aorta occlusion [82], tumor cachexia [11], or application of neurotoxin [69,80], distinctive muscle relaxants [81], neuroleptics [68,70], L-arginine [86], L-NAME [70,86], alcohol acute and chronic intoxication [63,64], and electrolytes disturbances [54,83,84,85])