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Stepwise addition of the FOXO4-DRI peptide to this complex caused the CSPs of FOXO4 to be reverted back to the unbound state, indicating FOXO4-DRI competes with FOXO4 for p53 binding in a dose-dependent manner and doing so with higher affinity (Fig

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Hyaline cartilage has a very unique architecture so that the top layers have collagen fibers oriented horizontally to resist shear forces, while the deeper layers have the collagen pointing vertically to absorb the compressive and impact forces