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To some degree, many studies have assumed the relationship between exposure and toxic response is dose dependant, however it is yet to be quantified and accepted

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GSH can be exhausted via inhibiting SLC7A11 by traditional drugs (e.g., sorafenib and sulfasalazine (SAS)) or novel compounds (e.g., erastin), thus inducing ferroptosis (Zhang et al., 2018), tumor protein 53 (TP53) (Sun et al., 2016)

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