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How Topical GHK-Cu May Work (Mechanisms) 1) Extracellular matrix (ECM) remodeling In vitro, ex vivo, and small clinical contexts, GHK-Cu has been reported to support collagen I/III , elastin , and glycosaminoglycan synthesis and to modulate MMP/TIMP activity—pathways central to dermal structure and resilience (PubMed

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These findings suggest that while Cys/CySS is the most abundant low-molecular-weight thiol-disulfide pool in plasma (23 times more abundant in plasma of healthy children than the GSH/GSSG pool), GSH is a better reducing agent than Cys as denoted by a more negative redox potential