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This finding is in line with results from other fields of research which showed that, while exercise does not appear to unbalance the pro- and anti-inflammatory response in healthy people, it may lead to an unbalanced and exaggerated inflammatory response in patients with pre-existing inflammatory conditions ( • The second study assessed circulating mitochondrial DNA (mtDNA) levels associated with exosomes in response to physical exercise

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Reductive carboxylation and fatty acid synthesis Cancer cells take up large amounts of glucose, but most of this carbon is excreted as lactate rather than metabolized in the TCA cycle 7 , potentially depriving the cells of the citrate derived from the TCA cycle that supports fatty acid synthesis (Figure 2)