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IM shots are often designed to release more slowly over several days

Molecular Biology

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3.3 Effective in vivo depletion of CD38+ lymphocytes by Daratumumab Daratumumab is a depleting antibody known to eliminate CD38-expressing B cells ( Figure 2A ) ( Supplementary Figure 2 ) ( Supplementary Figure 2 ), which may explain the compromised humoral anti-viral response by the patient ( Supplementary Figure 1 )