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This key effect of GSHee is connected to the findings that GSHee reduced the ability of fentanyl to lower pH, pO 2 and sO 2 while elevating pCO 2 (all consistent with a fall in Ve) and blunted the fentanyl-induced increase A-a-gradient (i.e., impaired gas-exchange in the lungs)
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A single course of phenobarbital for alcohol withdrawal (10-20 mg/kg cumulative dose within a short period of time) is unlikely to cause substantial enzyme induction
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