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This is important because 5% body weight loss is the threshold at which clinically meaningful health improvements typically begin, including reduced blood pressure, improved cholesterol profiles, and better glycemic control
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This effect was alleviated with both genetic and pharmacological inhibition of adipocyte lipolysis, which decreased hepatic acetyl-CoA levels and gluconeogenesis, thereby normalizing plasma glucose in mice fed with high fat diet (HFD) (183)
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