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These drugs are primarily utilized to improve non-motor symptoms, particularly when managing motor complications proves challenging
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Elevated insulin levels can drive AS through multiple mechanisms, including stimulation of very-low-density lipoprotein (VLDL) synthesis and secretion (117, 118), promotion of VSMC proliferation and growth (119, 120), activation of inflammation-related genes (121, 122), increased collagen synthesis (123, 124), and enhanced low-density lipoprotein (LDL) transport into smooth muscle cells (SMCs) (125, 126)