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The following represent contraindications or conditions requiring additional scrutiny based on the FDA-approved prescribing information and the clinical trial safety database: Disruption of the hypothalamic-pituitary axis due to hypophysectomy, hypopituitarism, pituitary tumor or surgery, head irradiation, or head trauma: tesamorelin requires an intact pituitary to generate GH secretion in response to GHRH receptor stimulation, and damage to this axis eliminates the pharmacological basis for the drug's effect Active malignancy or history of malignancy: IGF-1 elevation may have proliferative effects in the context of existing cancer, and providers carefully assess oncologic history before prescribing any compound that raises IGF-1 Pregnancy: tesamorelin should not be used during pregnancy
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