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As a result, the acute, injury-driven inflammatory response and the chronic, repair-oriented fibrotic process form a vicious cycle that jointly drives vascular structures toward irreversible occlusive lesions

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29 In the study of human MDD transcriptome, there are defects in the transcription levels of somatostatin (SST) in the subgenus anterior cingulate cortex and amygdala of MDD patients, 30,31 and SST levels are directly involved in the cellular processes that affect the synaptic output of intermediate neuronal circuits